On December 7, 2021, a 15-year-old male with Down syndrome and astigmatism, suffered a burn from sudden exposure to the flame of a water heater, which affected the skin area on his upper and lower eyelids. The skin lesion was diagnosed as a second-degree burn caused by physical heat. Prior to antiseptic therapy with CD, the eye was treated for the first 48 hours with Besifloxacin 0.6% ophthalmic suspension every 8 h and a Tobramycin/dexamethasone ointment (3mg/1mg/g) every 12 h, as recommended by another physician. After 48 h, the antibiotic treatment was suspended and on December 9, 2021, treatment with CD began. The first day of CD treatment consisted of three F15 protocols (30 ml CD at 3,000 ppm diluted in 1 L of H 2 O) taken orally every 3 h until finishing the liter, and on the application of protocol D (CD at 3,000 ppm diluted 1:3 in 0.9% NaCl) over the lesion every 2-3 h. The second day of treatment was a C20 protocol (20 ml CD at 3,000 ppm diluted in 1 L of H 2 O) taken orally every hour during 10 h until finishing the liter, and the application of protocol D to the lesion every 2–3 h. Between days 3 to 7 of treatment, a C20 protocol was taken, protocol D was applied and an ophthalmic suspension was added according to protocol O (5 ml CD at 3,000 ppm diluted in 50 ml of 0.9% NaCl with 3 ml of dimethyl sulfoxide, DMSO, at 70%) every 3-4 h. Between days 8 to 18 of the CD treatment, protocol D and O were followed. At the request of the parents, the CD treatment was supplemented with an ointment of Aloe vera and petrolatum topical on the skin. The skin was fully healed after day 22, and there was no change to the patient’s astigmatism diopters.